When manifestation of acute hemolytic reaction appear the nurse should immediately stop the transfusion process, maintain venous access with physiological saline, measure vital signs and call for urgent medical support, after that the nurse should rapidly inform the transfusion laboratory urgently and seek early support from critical care and hematology teams to admit the patient to an intensive care unit if possible. Also, nurse should give antihistaminic medications according to doctor order, after managing the case incident report should be done, (Napolitano et al
