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What is normal osmolarity?
290 mmos/l
What happens if there is water depreivation, solute ingestion,diarrhoea etc?
increased ECFosmolarity
What does increased ECF osmolarity lead to?
Detected by OSMORECEPTORS:
supraoptic ¶ventricularNuclei
lateralpreopticarea
What do the supraoptic and paraventricular Nuclei cause to happen?
ADH releasefrom posteriorpituitary
What does the ADH do?
CD made waterpermeable
What does increased water permeability of the CD lead to?
WATER RETENTION by Kidney returning plasma osmolarity back to normal
What does the lateral preoptic area stimulate?
thirst ---> drink water ----> plasma osmolarity returned to normal
Does the regulation of plasma osmolarity only work in this direction?
Regulation works in bothdirections
What does the tight control of ECF osmolarity mean for the regulation of ECF volume?
Since the osmolarity (i.e. water concentration) ofECF is tightly controlled,
the volume of the ECF is determined by the totalquantity of solute (mainly NaCl),
so regulation of ECF volume is all about sodiumbalance.
What does the dietary salt intake range between?
Dietary salt (NaCl) intake varies 0.05-25g/day.Average 2.3g/day
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